Principal Investigator

Dr. Abid Oueslati

Dr. Oueslati is an Assistant Professor in the Department of Molecular Medicine at Laval University, Director of the Molecular and Cellular Neurodegeneration Laboratory at the CHU Research Center in Quebec City, and a member of the management committee of l’Axe de Neurosciences-CHUL.

Dr. Oueslati obtained his Advanced Studies Diploma (ASD) in Neurobiology (2004), as well as his Doctorate in neuroscience (2008) at the Université de la Méditerranée Aix-Marseille – Faculté des Sciences de Luminy, Marseille-France. He then joined The Brain and Mind Institute at l’École Polytechnique Fédérale de Lausanne (EPFL), Switzerland, for a Postdoctoral fellowship in the group of Dr. Hilal A. Lashuel (2008-2014). After a short experience in the pharmaceutical industry at the ‘EPFL Innovation Parc’, he joined Laval University as Associate Professor (2014), and then as Assistant Professor in June 2015.

The research program developed by Dr. Oueslati and his colleagues aims to understand the involvement of protein misfolding and aggregation in neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease.

More specifically, Dr. Oueslati’s group are developing two lines of research:

  • Role of post-translational modifications in the regulation of aggregation and protein toxicity in neurodegenerative diseases. The goal of this line of research is to understand how chemical modifications (e.g. phosphorylation) affect the aggregation and toxicity of certain proteins in the brain, including alpha-synuclein protein in Parkinson’s disease, and tau and amyloid beta proteins in Alzheimer’s disease. The results of this project will allow, on the one hand to identify new markers for the early detection of neurodegenerative diseases, and on the other hand, they will allow to develop new therapeutic targets for these crippling diseases.

  • Role of prion propagation in the initiation and progression of neurodegenerative diseases. The goal of this project is to investigate how proteins involved in neurodegenerative diseases are able to spread from one neuron to another, and from one region of the brain to another, like prion disease. This spread of pathogenic proteins appears to play an important role in the initiation and progression of Parkinson’s disease and related diseases. The dissection of the molecular and cellular bases of this pathological propagation will allow to develop new therapeutic approaches that aim at stopping, or at least slowing, the progression of these neurodegenerative diseases.

Current Lab Members


Razan Sheta
Post-doctoral Fellow

Post-doctoral Fellow.


Morgan Bérard
Ph.D Student

Ph.D Student


Laura Martínez Drudis
Ph.D Student

Ph.D Student


Walid Idi
Ph.D Student

Ph.D Student


Maxime Teixeira
Ph.D Student

Maxime Teixeira's research interests are focused on the aggregation of the proteins involved in neurodegenerative diseases such as the alpha-synuclein in Parkinson’s disease. Using a new optogenetic model designed by our laboratory (LIPA system) which offers a unique spatiotemporality control of Lewy Body formation, Maxime is working on the interaction between aggregates and the vesicles and organelles in order to better understand how is mediated alpha-symuclein aggregation to open new possibilities to find new therapeutic targets.

Raquel Rodriguez Aller
Ph.D Student

Ph.D Student


Julie Pilon
M.Sc Intern

B.Sc Intern

Camille Lupiet
M.Sc Intern

B.Sc Intern