2022

PLOS Biology | March, 2022

A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

Morgan Bérard*, Razan Sheta*, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Salesse, Jérôme Lamontagne-Proulx, Marie-Kim St-Pierre, Omid Tavassoly, Wen Luo, Del Cid-Pellitero, Raza Qazi, Jae-Woong Jeong, Thomas Martin Durcan, Luc Vallières, Marie-Eve Tremblay, Denis Soulet, Martin Lévesque, Francesca Cicchetti, Edward A Fon, Armen Saghatelyan, Abid Oueslati.
* Equal contributions.

2021

Biomolecules | September, 2021

Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association

Maxime Teixeira,* Razan Sheta*, Walid Idi and Abid Oueslati.
* Equal contributions.

Molecular Psychiatry | September, 2021

Shedding a new light on Huntington’s disease: How blood can both propagate and ameliorate disease pathology

Marie Rieux, Melanie Alpaugh, Giacomo Sciacca, Martine Saint-Pierre, Maria Masnata, Hélèna L Denis, Sébastien A Lévesque, Frank Herrmann, Chantal Bazenet, Alexandre P Garneau, Paul Isenring, Ray Truant, Abid Oueslati, Peter V Gould, Anne Ast, Erich E Wanker, Steve Lacroix, Francesca Cicchetti.

2020

Neurobiology of Disease | July, 2020

Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates

Alexander Maxan, Giacomo Sciacca, Melanie Alpaugh, Zhu Tao, Ludivine Breger, Benjamin Dehay, Zhang Ling, Qin Chuan, Giulia Cisbani, Maria Masnata, Shireen Salem, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti.

Neurobiology of Disease | July, 2020

Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates

Philippe Gosset, Alexander Maxan, Melanie Alpaugh, Ludivine Breger, Benjamin Dehay, Zhu Tao, Zhang Ling, Chuan Qin, Giulia Cisbani, Nadia Fortin, Jean-Paul G Vonsattel, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti.

Neurobiology of Disease | July, 2020

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Stefan Bartl, Abid Oueslati, Amber L Southwell, Alberto Siddu, Michela Parth, Linda Suzanne David, Alexander Maxan, Nina Salhat, Markus Burkert, Andreas Mairhofer, Theresa Friedrich, Halyna Pankevych, Katja Balazs, Guenther Staffler, Michael R Hayden, Francesca Cicchetti, Oskar W Smrzka.

2017

Journal of Biological Chemistry | March, 2017

Dissecting the molecular pathway involved in PLK2 kinase-mediated α-synuclein-selective autophagic degradation

Manel Dahmene, Morgan Bérard, Abid Oueslati.

2016

Acta Neuropathologica | October, 2016

Human-to-mouse prion-like propagation of mutant huntingtin protein

Iksoo Jeon, Francesca Cicchetti, Giulia Cisbani, Suji Lee, Endan Li, Jiwoo Bae, Nayeon Lee, Ling Li, Wooseok Im, Manho Kim, Hyun Sook Kim, Seung-Hun Oh, Tae-Aug Kim, Jung Jae Ko, Benoit Aubé, Abid Oueslati, Yun Joong Kim, Jihwan Song

Proceedings of the National Academy of Sciences | February, 2016

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

Mohamed-Bilal Fares, Bohumil Maco, Abid Oueslati, Edward Rockenstein, Natalia Ninkina, Vladimir L Buchman, Eliezer Masliah, Hilal A Lashuel

Journal of Parkinson's disease | February, 2016

Implication of alpha-synuclein phosphorylation at S129 in synucleinopathies: what have we learned in the last decade?

Abid Oueslati

2015

PLOS One | October, 2015

Photobiomodulation suppresses alpha-synuclein-induced toxicity in an AAV-based rat genetic model of Parkinson’s disease

Abid Oueslati, Blaise Lovisa, John Perrin, Georges Wagnieres, Hubert van den Bergh, Yanik Tardy, Hilal A Lashuel

Journal of Biological Chemistry | April, 2015

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo

Martial Kamdem Mbefo, Mohamed-Bilal Fares, Katerina Paleologou, Abid Oueslati, Guowei Yin, Sandra Tenreiro, Madalena Pinto, Tiago Outeiro, Markus Zweckstetter, Eliezer Masliah, Hilal A Lashuel

2014

Experimental Neurobiology | December, 2014

Protein transmission, seeding and degradation: key steps for α-synuclein prion-like propagation

Abid Oueslati, Methodios Ximerakis, Kostas Vekrellis

Human Molecular Genetics | August, 2014

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

Anne-Laure Mahul-Mellier, Bruno Fauvet, Amanda Gysbers, Igor Dikiy, Abid Oueslati, Sandrine Georgeon, Allan J Lamontanara, Alejandro Bisquertt, David Eliezer, Eliezer Masliah, Glenda Halliday, Oliver Hantschel, Hilal A Lashuel

2013

Proceedings of the National Academy of Sciences | October, 2013

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

Abid Oueslati, Bernard L Schneider, Patrick Aebischer, Hilal A Lashuel

Nature Reviews Neuroscience | January, 2013

The many faces of α-synuclein: from structure and toxicity to therapeutic target

Hilal A Lashuel, Cassia R Overk, Abid Oueslati, Eliezer Masliah

2012

Journal of Neuroscience | February, 2012

Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease

Abid Oueslati, Katerina E Paleologou, Bernard L Schneider, Patrick Aebischer, Hilal A Lashuel

2010

Journal of Neuroscience | March, 2010

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions

Katerina E Paleologou, Abid Oueslati, Gideon Shakked, Carla C Rospigliosi, Hai-Young Kim, Gonzalo R Lamberto, Claudio O Fernandez, Adrian Schmid, Fariba Chegini, Wei Ping Gai, Diego Chiappe, Marc Moniatte, Bernard L Schneider, Patrick Aebischer, David Eliezer, Markus Zweckstetter, Eliezer Masliah, Hilal A Lashuel

Journal of Biological Chemistry | January, 2010

Phosphorylation of synucleins by members of the Polo-like kinase family

Martial K Mbefo, Katerina E Paleologou, Ahmed Boucharaba, Abid Oueslati, Heinrich Schell, Margot Fournier, Diana Olschewski, Guowei Yin, Markus Zweckstetter, Eliezer Masliah, Philipp J Kahle, Harald Hirling, Hilal A Lashuel

Progress in Brain Research | January, 2010

Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: implications for Parkinson’s disease pathogenesis and therapies

Abid Oueslati, Margot Fournier, Hilal A Lashuel

2009

Neurobiology of Disease | October, 2009

Different functional basal ganglia subcircuits associated with anti-akinetic and dyskinesiogenic effects of antiparkinsonian therapies

Emilie Lacombe, Vitaly Khaindrava, Christophe Melon, Abid Oueslati, Lydia Kerkerian-Le Goff, Pascal Salin

2007

Journal of Neuroscience | February, 2007

High-frequency stimulation of the subthalamic nucleus potentiates L-DOPA-induced neurochemical changes in the striatum in a rat model of Parkinson's disease

Abid Oueslati, Véronique Sgambato-Faure, Christophe Melon, Philippe Kachidian, Paolo Gubellini, Mohammed Amri, Lydia Kerkerian-Le Goff, Pascal Salin

2006

European Journal of Neuroscience | September, 2006

Chronic high‐frequency stimulation of the subthalamic nucleus and L‐DOPA treatment in experimental parkinsonism: effects on motor behaviour and striatal glutamate transmission

Paolo Gubellini, Alexandre Eusebio, Abid Oueslati, Christophe Melon, Lydia Kerkerian‐Le Goff, Pascal Salin

2005

European Journal of Neuroscience | December, 2005

Dysfunction of the cortico‐basal ganglia‐cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism

Abid Oueslati, Nathalie Breysse, Marianne Amalric, Lydia Kerkerian‐Le Goff, Pascal Salin